The nurse should instruct a client on chemotherapy to have which of the following precautions regarding fluid intake?

The suggestion to increase fluid intake to help with medication clearance is important for clients undergoing chemotherapy. Chemotherapy drugs can be metabolically demanding on the body, and they may also contribute to nephrotoxicity, which can impair kidney function. Adequate hydration is essential in helping the kidneys effectively filter these drugs and their metabolites from the body. By increasing fluid intake, patients can support renal function, promote diuresis, and facilitate the excretion of toxic substances released during cancer treatment.

Additionally, proper hydration can assist in mitigating some of the side effects associated with chemotherapy, such as constipation and dehydration, which can exacerbate other symptoms. Ensuring that clients consume sufficient fluids can be a key component in helping them cope with the overall treatment process, thus improving their comfort and potentially enhancing their response to the therapy.